National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Refractory Sprue is not the name you expected.
Refractory sprue (RS) is a complex autoimmune disorder much like the more common celiac sprue but, unlike celiac sprue, it is resistant or unresponsive to six months of treatment with a strict gluten-free diet. Gliadin, a component of the wheat storage protein gluten, together with similar proteins in barley and rye, are the villains that trigger the immune reaction in celiac sprue. The diagnosis of RS is made by exclusion, especially of any other disorder that can affect the huge number of thread-like projections that line the interior of the intestine (intestinal villi), such as intestinal lymphoma, Crohn's disease, small intestinal bacterial overgrowth or hypogammaglobulinemia.
The intestinal villi are the means by which the gut absorbs fluids and nutrients. In celiac sprue and refractory sprue, these villi shrink and shrivel (atrophy) affecting the absorption of nutrients via the intestines. In celiac sprue, treatment by means of a strict gluten-free diet is usually sufficient to overcome the disorder. However, refractory sprue is just that: refractory or stubbornly resistant to treatment. Only a small percentage of the people with celiac sprue will develop RS, and these patients are almost invariably 30 years of age or older. However, as yet, it is impossible to predict which patient of those with celiac sprue will develop RS.
Academy of Nutrition and Dietetics
- 120 South Riverside Plaza, Suite 2000
- Chicago, IL 60606-6995
- Tel: (312)899-0400
- Fax: (312)899-4899
- Tel: (800)877-1600
- Email: email@example.com
- Website: http://www.eatright.org
Association of Gastrointestinal Motility Disorders, Inc. (AGMD)
- 12 Roberts Drive
- Bedford, MA 1730
- Tel: (781)275-1300
- Fax: (781)275-1304
- Email: firstname.lastname@example.org.
- Website: http://www.agmd-gimotility.org
Celiac Disease Foundation
- 20350 Ventura Blvd
- Ste 240
- Woodland Hills, CA 91364
- Tel: (818)716-1513
- Fax: (818)267-5577
- Email: email@example.com
- Website: http://www.celiac.org
Celiac Sprue Association
- P.O. Box 31700
- Omaha, NE 68131-0700
- Tel: (402)558-0600
- Fax: (402)643-4108
- Tel: (877)272-4272
- Email: firstname.lastname@example.org
- Website: http://www.csaceliacs.org
Crohn's and Colitis Foundation of America
- 386 Park Avenue South
- 17th Floor
- New York, NY 10016-7374
- Tel: (212)685-3440
- Fax: (212)779-4098
- Tel: (800)932-2423
- Email: email@example.com
- Website: http://www.ccfa.org
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
- Tel: (888)205-2311
- Website: http://rarediseases.info.nih.gov/GARD/
Gluten Intolerance Group of North America
- 31214 124th Ave SE
- Auburn, WA 98092
- Tel: (253)833-6655
- Fax: (253)833-6675
- Email: firstname.lastname@example.org
- Website: http://www.gluten.net
International Foundation for Functional Gastrointestinal Disorders
- 700 W. Virginia St., 201
- Milwaukee, WI 53217
- Tel: (414)964-1799
- Fax: (414)964-7176
- Tel: (888)964-2001
- Email: email@example.com
- Website: http://www.iffgd.org
NIH/National Institute of Diabetes, Digestive & Kidney Diseases
- Office of Communications & Public Liaison
- Bldg 31, Rm 9A06
- Bethesda, MD 20892-2560
- Tel: (301)496-3583
- Email: NDDIC@info.niddk.nih.gov
- Website: http://www2.niddk.nih.gov/
National Foundation for Celiac Awareness
- P.O. Box 544
- 224 South Maple Street
- Ambler, PA 19002
- Tel: (215)325-1306
- Fax: (215)643-1707
- Email: firstname.lastname@example.org
- Website: http://www.CeliacCentral.org
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 3/28/2016
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