Reactive Arthritis

National Organization for Rare Disorders, Inc.

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Important
It is possible that the main title of the report Reactive Arthritis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Fiessinger-Leroy disease
  • Reiter's syndrome

Disorder Subdivisions

  • None

General Discussion

Reactive arthritis is a general term for a form of joint inflammation (arthritis) that develops as a "reaction" to an infection in another area of the body (i.e., outside of the joints). Joint inflammation is characterized by redness, swelling, pain and warmth in and around the affected joint. In reactive arthritis, the large joints of the lower limbs and the sacroiliac joints are most often affected. Two other common symptoms of reactive arthritis are inflammation of the urinary tract and inflammation of the membrane (conjunctiva) that lines the eyelids (conjunctivitis). These three characteristic symptoms may occur separately, all at once or not at all. Additional symptoms such as fever, weight loss, lower back pain and heel pain may also occur. Reactive arthritis usually develops following a bout with certain bacterial infections including Chlamydia, Salmonella, Shigella, Yersinia, and Campylobacter.

Reactive arthritis belongs to a group of related disorders known as the spondyloarthropathies. These disorders are linked by the association of similar symptoms and a specific genetic marker called HLA-B27. Symptoms common to these disorders include arthritis, especially of the lower limbs, lower back pain and enthesitis, a condition characterized by inflammation at the spot where skeletal muscle attaches to bone. This group of disorders includes reactive arthritis, ankylosing spondylitis, psoriatic arthritis, undifferentiated spondyloarthritis and spondyloarthritis associated with inflammatory bowel disease.

Reactive arthritis is a poorly defined disorder that has been described in the medical literature under many different names. No precise diagnostic or classification criteria have been developed that are universally agreed upon in the medical community.

Supporting Organizations

American Autoimmune & Related Diseases

22100 Gratiot Ave.
Eastpointe, MI 48021
Tel: (586)776-3900
Fax: (586)776-3903
Tel: (800)598-4668
Email: aarda@aarda.org
Website: http://www.aarda.org/

Arthritis Foundation

1330 West Peachtree Street, Suite 100
Atlanta, GA 30309
USA
Tel: (404)872-7100
Tel: (800)283-7800
Email: arthritisfoundation@arthritis.org
Website: http://www.arthritis.org

Arthritis Society

393 University Avenue
Suite 1700
Ontario, M5G IE6
Canada
Tel: 4169797228
Fax: 4169798366
Tel: 8003211433
Email: info@arthritis.ca
Website: http://www.arthritis.ca

Autoimmune Information Network, Inc.

PO Box 4121
Brick, NJ 8723
Fax: (732)543-7285
Email: autoimmunehelp@aol.com

Centers for Disease Control and Prevention

1600 Clifton Road NE
Atlanta, GA 30333
Tel: (404)639-3534
Tel: (800)232-4636
Email: cdcinfo@cdc.gov
Website: http://www.cdc.gov/

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
Website: http://rarediseases.info.nih.gov/GARD/

KickAS.org

11688 North Sage Brook Road
Oro Valley, AZ 85737-7342
Tel: (520)544-3023
Fax: (520)544-3023
Email: kickas@gmail.com
Website: http://www.kickas.org

NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

Information Clearinghouse
One AMS Circle
Bethesda, MD 20892-3675
USA
Tel: (301)495-4484
Fax: (301)718-6366
Tel: (877)226-4267
Email: NIAMSinfo@mail.nih.gov
Website: http://www.niams.nih.gov/

Ocular Immunology and Uveitis Foundation

5 Cambridge Center
8th Floor
Cambridge, MA 2142
Tel: (617)621-6377
Fax: (781)431-2042
Tel: (866)353-6377
Email: fosters@comcast.net
Website: http://www.uveitis.org

Sexuality Information and Education Council of the U.S.

90 John St.
Suite 704
New York, NY 10038
Tel: (212)819-9770
Fax: (212)819-9776
Email: pmalone@siecus.org
Website: http://www.siecus.org

Spondylitis Association of America

P.O. Box 5972
Sherman Oaks, CA 91413
USA
Tel: (818)892-1616
Fax: (818)892-1611
Tel: (800)777-8189
Email: info@spondylitis.org
Website: http://www.spondylitis.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  12/30/1969
Copyright  2013 National Organization for Rare Disorders, Inc.