National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Hereditary Angioedema is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- Angioneurotic Edema, Hereditary
- Complement Component 1 Inhibitor Deficiency
- Complement Component C1, Regulatory Component Deficiency
- Esterase Inhibitor Deficiency
Hereditary angioedema is a rare inherited disorder characterized by recurrent episodes of the accumulation of fluids outside of the blood vessels, blocking the normal flow of blood or lymphatic fluid and causing rapid swelling of tissues in the hands, feet, limbs, face, intestinal tract, or airway. Usually, this swelling is not accompanied by itching, as it might be with an allergic reaction. Swelling of the gastrointestinal tract leads to cramping. Swelling of the airway may lead to obstruction, a potentially very serious complication. These symptoms develop as the result of deficiency or improper functioning of certain proteins that help to maintain the normal flow of fluids through very small blood vessels (capillaries). In some cases, fluid may accumulate in other internal organs. The severity of the disease varies greatly among affected individuals.
The most common form of the disorder is hereditary angioedema type I, which is the result of abnormally low levels of certain complex proteins in the blood (C1 esterase inhibitors), known as complements. They help to regulate various body functions (e.g., flow of body fluids in and out of cells). Hereditary angioedema type II, a more uncommon form of the disorder, occurs as the result of the production of abnormal complement proteins.
American Academy of Allergy, Asthma and Immunology
- 611 East Wells Street
- Milwaukee, WI 53202
- Tel: (414)272-6071
- Fax: (414)276-3349
- Tel: (800)822-2762
- Email: firstname.lastname@example.org
- Website: http://www.aaaai.org
European Society for Immunodeficiencies
- 1-3 rue de Chantepoulet
- Geneva, CH 1211
- Tel: 410229080484
- Fax: 41229069140
- Email: email@example.com
- Website: http://www.esid.org
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
- Tel: (888)205-2311
- Website: http://rarediseases.info.nih.gov/GARD/
Immune Deficiency Foundation
- 110 West Road
- Suite 300
- Towson, MD 21204
- Tel: (410)321-6647
- Fax: (410)321-9165
- Tel: (800)296-4433
- Email: firstname.lastname@example.org
- Website: http://www.primaryimmune.org
NIH/National Institute of Allergy and Infectious Diseases
- NIAID Office of Communications and Government Relations
- 5601 Fishers Lane, MSC 9806
- Bethesda, MD 20892-9806
- Tel: (301)496-5717
- Fax: (301)402-3573
- Tel: (866)284-4107
- Email: email@example.com
- Website: http://www.niaid.nih.gov/
US Hereditary Angioedema Association, Inc.
- Seven Waterfront Plaza
- 500 Ala Moana Blvd., Suite 400
- Honolulu, HI 96813
- Fax: (508)437-0303
- Tel: (866)798-5598
- Email: firstname.lastname@example.org
- Website: http://www.haea.org
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 1/6/1970
Copyright 2008 National Organization for Rare Disorders, Inc.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.