Neuroleptic Malignant Syndrome
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Neuroleptic Malignant Syndrome is not the name you expected.
Neuroleptic malignant syndrome is a rare but potentially life-threatening reaction to the use of almost any of a group of antipsychotic drugs or major tranquilizers (neuroleptics). These drugs are commonly prescribed for the treatment of schizophrenia and other neurological, mental, or emotional disorders. Several of the more commonly prescribed neuroleptics include thioridazine, haloperidol, chlorpromazine, fluphenazine and perphenazine.
The syndrome is characterized by high fever, stiffness of the muscles, altered mental status (paranoid behavior), and autonomic dysfunction. Autonomic dysfunction alludes to defective operations of the components of the involuntary (autonomic) nervous system, leading to wide swings of blood pressure, excessive sweating and excessive secretion of saliva.
A genetic basis for the disorder is suspected but not proven. It does appear to be clear that a defect in the receptors to dopamine (dopamine D2 receptor antagonism) is an important contributor to the cause of neuroleptic malignant syndrome.
Malignant Hyperthermia Association of the United States
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Mental Health America
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NIH/National Institute of Mental Health
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National Alliance on Mental Illness
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National Mental Health Consumers' Self-Help Clearinghouse
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North American Malignant Hyperthermia Registry
- Penn State University
- Dept. of Anesthesiology
- Hershey, PA 17033-0850
- Tel: (412)692-6390
- Fax: (412)692-8658
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For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
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This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 5/1/2008
Copyright 2004 National Organization for Rare Disorders, Inc.
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