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Paget's Disease of the Breast

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Paget's Disease of the Breast is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • mammary Paget's disease
  • Paget's disease of the nipple
  • Paget's disease of the nipple and areola

Disorder Subdivisions

  • None

General Discussion

Summary

Paget's disease of the breast is a rare form of breast cancer that almost exclusively occurs in women. However, rare cases have been reported in men. Paget's disease of the breast is characterized by inflammatory, "eczema-like" changes of the nipple that may extend to involve the areola, which is the circular, darkened (pigmented) region of skin surrounding the nipple. Initial findings often include itching (pruritus), scaling, and crusting of and/or discharge from the nipple. In individuals with Paget's disease of the breast, distinctive tumor cells (known as Paget cells) are present within the outermost layer of skin (epidermis) of the nipple, when viewed under a microscope. Most women with this disorder have an underlying cancer (malignancy) affecting the milk ducts (ductal carcinoma). The milk ducts are the channels that carry milk secreted by lobes of the breast to the nipple. The exact cause of Paget's disease of the breast is not fully understood.



Introduction

Paget's disease of the breast was originally reported in 1874 by Sir James Paget, an English surgeon, who also described an unrelated skeletal condition known as Paget's disease of the bone. It is essential to note that these disorders are distinct entities that are medically unrelated.

Resources

National Women's Health Network

1413 K Street, NW

4th Floor

Washington, DC 20005

USA

Tel: (202)682-2640

Fax: (202)682-2648

Email: nwhn@nwhn.org

Internet: http://www.womenshealthnetwork.org



Skin Cancer Foundation

149 Madison Avenue

Suite 901

New York, NY 10016

Tel: (212)725-5176

Fax: (212)725-5751

Tel: (800)754-6490

Email: info@skincancer.org

Internet: http://www.skincancer.org



American Cancer Society, Inc.

250 Williams NW St

Ste 6000

Atlanta, GA 30303

USA

Tel: (404)320-3333

Tel: (800)227-2345

TDD: (866)228-4327

Internet: http://www.cancer.org



Rose Kushner 's Women's Breast Cancer Advisory Center

P.O. Box 757

Malaga Cove, CA 90274

Email: lkkushner@yahoo.com

Internet: http://www.rkbcac.org/



National Cancer Institute Physician Data Query

Office of Communications and Education

Public Inquiries Office

6116 Executive Blvd

Suite 300

Bethesda, MD 20892-8322

Tel: (800)422-6237

Email: cancergovstaff@mail.nih.gov

Internet: http://www.cancer.gov/cancertopics/pdq/cancerdatabase



National Cancer Institute

6116 Executive Blvd Suite 300

Bethesda, MD 20892-8322

USA

Tel: (301)435-3848

Tel: (800)422-6237

TDD: (800)332-8615

Email: cancergovstaff@mail.nih.gov

Internet: http://www.cancer.gov



OncoLink: The University of Pennsylvania Cancer Center Resource

3400 Spruce Street

2 Donner

Philadelphia, PA 19104-4283

USA

Tel: (215)349-8895

Fax: (215)349-5445

Email: hampshire@uphs.upenn.edu

Internet: http://www.oncolink.upenn.edu



SHARE - Self-Help For Women With Breast or Ovarian Cancer

1501 Broadway

Suite 704A

New York, NY 10036

Tel: (212)719-0364

Fax: (212)869-3431

Tel: (866)891-2392

Email: info@sharecancersupport.org

Internet: http://www.sharecancersupport.org/



Canadian Breast Cancer Network

331 Cooper Street, Suite 300

Ottawa

Ontario, K2P 0G5

Canada

Tel: 6132303044

Fax: 6132304424

Tel: 8006858820

Email: cbcn@cbcn.ca

Internet: http://www.cbcn.ca



Breast Cancer Society of Canada

420 East Street North

Sarnia

Ontario, N7T 6Y5

Canada

Tel: 5193360746

Fax: 5193365725

Tel: 8005678767

Email: bcsc@bcsc.ca

Internet: http://www.bcsc.ca



Rare Cancer Alliance

1649 North Pacana Way

Green Valley, AZ 85614

USA

Internet: http://www.rare-cancer.org



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



Friends of Cancer Research

1800 M Street NW

Suite 1050 South

Washington, DC 22202

Tel: (202)944-6700

Email: info@focr.org

Internet: http://www.focr.org



Cancer Support Community

1050 17th St NW Suite 500

Washington, DC 20036

Tel: (202)659-9709

Fax: (202)974-7999

Tel: (888)793-9355

Internet: http://www.cancersupportcommunity.org/



Lance Armstrong Foundation

2201 E. Sixth Street

Austin, TX 78702

Tel: (512)236-8820

Fax: (512)236-8482

Tel: (877)236-8820

Email: media@livestrong.org

Internet: http://www.livestrong.org



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  3/27/2012

Copyright  1990, 2000, 2012 National Organization for Rare Disorders, Inc.

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