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It is possible that the main title of the report Lymphangioleiomyomatosis is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Lymphangioleiomyomatosis (LAM) is a rare progressive multisystem disorder that predominantly affects women of childbearing age. It occurs in women who have tuberous sclerosis, and also in women who do not have a heritable genetic disorder. LAM is characterized by the spread and uncontrolled growth (proliferation) of specialized cells (smooth muscle-like LAM cells) in certain organs of the body, especially the lungs, kidney and lymphatics. Common symptoms associated with LAM include coughing and/or difficulty breathing (dyspnea), especially following periods of exercise or exertion. Affected individuals may also experience complications including collapse of a lung or fluid accumulation around the lungs (pleural effusion). The disorder is progressive and, in some cases, may result in chronic respiratory failure.

Supporting Organizations

American Lung Association

55 W. Wacker Drive
Suite 1150
Chicago, IL 60601
Tel: 1-800-548-8252

British Lung Foundation

73-75 Goswell Road
London, EC1V 7ER
United Kingdom
Tel: 0207 688 5555
Tel: 3000030555

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311

LAM Health Project

1909 Capitol Avenue,
Suite 203
Sacramento, CA 95811
Tel: (617)460-7339
Fax: (617)864-0614

Lymphatic Malformation Institute

7475 Wisconsin Ave
Suite 600
Bethesda, MD 20814

NIH/National Heart, Lung and Blood Institute

P.O. Box 30105
Bethesda, MD 20892-0105
Tel: (301)592-8573
Fax: (301)251-1223

Second Wind Lung Transplant Association, Inc.

P.O. Box 1657
Wimberley, TX 78676-1657
Tel: (512)847-9303
Tel: (888)855-9463

The LAM Foundation

4015 Executive Park Drive, Suite 320
Cincinnati, OH 45241
Tel: (513)777-6889
Fax: (513)777-4109
Tel: (877)287-3526

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated:  7/21/2015
Copyright  2009 National Organization for Rare Disorders, Inc.