Limb-Girdle Muscular Dystrophies
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Limb-Girdle Muscular Dystrophies is not the name you expected.
Limb-girdle muscular dystrophies (LGMD) are a group of rare progressive genetic disorders that are characterized by wasting (atrophy) and weakness of the voluntary muscles of the hip and shoulder areas (limb-girdle area). Muscle weakness and atrophy are progressive and may spread to affect other muscles of the body. Many different subtypes have been identified based upon abnormal changes (mutations) of certain genes. The age at onset, severity, and progression of symptoms of these subtypes may vary greatly from case to case, even among individuals in the same family. Some individuals may have a mild, slowly progressive form of the disorders; other may have a rapidly progressive form of the disorder that causes severe disability.
The term limb-girdle muscular dystrophies is a general term that encompasses several disorders. These disorders can now be distinguished by genetic and protein analysis. The various forms of LGMD may be inherited as autosomal dominant or recessive traits. Autosomal dominant LGMD is known as LGMD1 and there are currently recognized eight subtypes (LGMD1A-1H). Autosomal recessive LGMD is known as LGMD2 and has 17 subtypes (LGMDA-Q).
Additional terminology has been used in the past to describe forms of muscular dystrophy that are now classified under LGMD. These terms are no longer widely used and include scapulohumeral (Erb) muscular dystrophy, pelvifemoral (Leyden-Mobius) muscular dystrophy, and severe childhood autosomal recessive muscular dystrophy (SCARMD).
Child Neurology Foundation
- 201 Chicago Ave, #200
- Minneapolis, MN 55415
- Tel: (952)641-6100
- Fax: (952)881-6276
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- Website: http://www.childneurologyfoundation.org
Cure CMD (Congenital Muscular Dystrophy)
- P.O. Box 701
- Olathe, KS 66051
- Tel: (866)400-3626
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- Website: http://www.curecmd.org
Genetic and Rare Diseases (GARD) Information Center
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- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
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- Website: http://rarediseases.info.nih.gov/GARD/
Global FKRP Registry
- TREAT-NMD Office
- Institute of Genetic Medicine
- Newcastle upon Tyne, NE1 3BZ
- United Kingdom
- Tel: 4401912418617
- Fax: 4401912418770
- Email: firstname.lastname@example.org
- Website: https://www.fkrp-registry.org/
Jain Foundation Inc.
- 9725 Third Avenue NE
- Suite 204
- Seattle, WA 98115
- Tel: (425)882-1492
- Fax: (240)282-0510
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- Website: http://www.jain-foundation.org
LGMD2I Research Fund
- PO Box 245
- Bellevue, WA 98009
- Tel: (425)460-2554
- Fax: (425)460-1236
- Email: firstname.lastname@example.org
- Website: http://www.lgmd2ifund.org
Let Them Hear Foundation
- 1900 University Avenue, Suite 101
- East Palo Alto, CA 94303
- Tel: (650)462-3174
- Fax: (650)462-3144
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- Website: http://www.letthemhear.org
Muscular Dystrophy Association
- 3300 East Sunrise Drive
- Tucson, AZ 85718-3208
- Tel: (520)529-2000
- Fax: (520)529-5300
- Tel: (800)572-1717
- Email: firstname.lastname@example.org
- Website: http://www.mda.org/
Muscular Dystrophy Campaign
- 61 Southwark Street
- London, SE1 0HL
- United Kingdom
- Tel: 2078034800
- Email: email@example.com
- Website: http://www.muscular-dystrophy.org
NIH/National Institute of Neurological Disorders and Stroke
- P.O. Box 5801
- Bethesda, MD 20824
- Tel: (301)496-5751
- Fax: (301)402-2186
- Tel: (800)352-9424
- Website: http://www.ninds.nih.gov/
New Horizons Un-Limited, Inc.
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- P.O. Box 510034
- Milwaukee, WI 53203
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- Fax: (414)347-1977
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- Website: http://www.new-horizons.org
Society for Muscular Dystrophy Information International
- P.O. Box 7490
- Nova Scotia, B4V 2X6
- Tel: 9026853961
- Fax: 9026853962
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- Website: http://www.nsnet.org/smdi/
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 6/2/2015
Copyright 2012 National Organization for Rare Disorders, Inc.
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