National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Holoprosencephaly is not the name you expected.
Holoprosencephaly (HPE) is the failure of the prosencephalon, or forebrain, to develop normally. The forebrain is a region of the brain in the fetus that develops into parts of the adult brain, including the cerebral cortex. Instead of the normal complete separation of the left and right halves of the forebrain, there is an abnormal continuity between the two sides.
There are several different types of holoprosencephaly. In the alobar form, there is no separation between the right and left halves at all. In semilobar HPE, at least some separation of the two halves is present. In the lobar form, most of the brain has separated into right and left sides, though there is incomplete division into the two halves.
Carter Centers for Brain Research in Holoprosencephaly and Related Malformations
- Texas Scottish Rite Hospital for Children, Department of Neurology
- 2222 Welborn Street
- Dallas, TX 75219-3993
- Tel: (214)559-8411
- Fax: (214)559-8383
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- Website: http://www.carterdatabase.org/hpe
Genetic and Rare Diseases (GARD) Information Center
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- Gaithersburg, MD 20898-8126
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- Tel: (888)205-2311
- Website: http://rarediseases.info.nih.gov/GARD/
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NIH/National Institute of Child Health and Human Development
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- Building 31, Room 2A32
- Bethesda, MD 20892
- Fax: (866)760-5947
- Tel: (800)370-2943
- Email: NICHDInformationResourceCenter@mail.nih.gov
- Website: http://www.nichd.nih.gov/
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 6/1/2015
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