Factor XIII Deficiency
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Factor XIII Deficiency is not the name you expected.
Factor XIII deficiency is a rare, genetic bleeding disorder characterized by deficiency of clotting factor XIII. Clotting factors are specialized proteins that are essential for the blood to clot properly. Specifically, individuals with factor XIII deficiency form blood clots like normal, but these clots are unstable and often break down, resulting in prolonged, uncontrolled bleeding episodes. Factor XIII also affects other processes in the body and is known to play a role in proper wound healing and pregnancy. The severity of factor XIII deficiency bleeds can vary greatly from one person to another. Some individuals may have only mild symptoms; other individuals may have severe, life-threatening bleeds. With early diagnosis and prompt treatment, the more serious bleeds of factor XIII deficiency can be avoided. FXIII consists of two subunits: subunit A and subunit B. Most of the Factor XIII deficiency states are caused by mutations in subunit A; very few have a mutation in subunit B. Factor XIII deficiency is inherited as an autosomal recessive disorder.
This report deals with the genetic form of factor XIII deficiency, which is present at birth (congenital); the disorder can also be acquired during life. Although the genetic form is present at birth, symptoms may not become apparent until later during life. Congenital factor XIII deficiency was first described in the medical literature by Duckert, et al., in 1960.
Canadian Hemophilia Society
- 301-666 Sherbrooke Street West
- Montreal, QC H3A 1E7
- Tel: 5148480503
- Fax: 5148489661
- Tel: 8006682686
- Email: firstname.lastname@example.org
- Website: http://www.hemophilia.ca
Children's Cancer & Blood Foundation
- 333 East 38th Street, Suite 830
- New York, NY 10016-2745
- Tel: (212)297-4336
- Fax: (212)297-4340
- Email: email@example.com
- Website: http://www.childrenscbf.org/
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
- Tel: (888)205-2311
- Website: http://rarediseases.info.nih.gov/GARD/
Hemophilia Federation of America
- 210 7th St. SE
- Suite 200B
- Washington, DC 20003
- Tel: (202)675-6984
- Fax: (202)675-6983
- Tel: (800)230-9797
- Email: firstname.lastname@example.org
- Website: http://www.hemophiliafed.org
Irish Haemophilia Society
- First Floor
- Cathedral Court
- Dublin, 7
- Tel: 353016579900
- Fax: 353016579901
- Email: email@example.com
- Website: http://www.haemophilia.ie/
NIH/National Heart, Lung and Blood Institute
- P.O. Box 30105
- Bethesda, MD 20892-0105
- Tel: (301)592-8573
- Fax: (301)251-1223
- Email: firstname.lastname@example.org
- Website: http://www.nhlbi.nih.gov/
National Hemophilia Foundation
- 116 West 32nd Street, 11th Floor
- New York, NY 10001
- Tel: (212)328-3700
- Fax: (212)328-3777
- Tel: (800)424-2634
- Email: email@example.com
- Website: http://www.hemophilia.org
World Federation of Hemophilia
- 1425, boul. René-Lévesque O.
- Bureau 1010
- Montréal, Québec, H3G 1T7
- Tel: +1 (514) 875-7944
- Fax: +1 (514) 875-8916
- Email: firstname.lastname@example.org
- Website: http://www.wfh.org/en/page.aspx?pid=492
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 8/12/2015
Copyright 2012 National Organization for Rare Disorders, Inc.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.