Acquired Aplastic Anemia
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Acquired Aplastic Anemia is not the name you expected.
Acquired aplastic anemia is a rare, serious blood disorder, due to failure of the bone marrow failure to produce blood cells. Bone marrow is the spongy substance found in the center of the bones of the body, in adults mainly the spine, pelvis, and large bones of the legs. The bone marrow contains hematopoietic stem cells. Stem cells can produce more stem cells (self-renewal) and also differentiate and proliferate, giving rise to red blood cells (erythrocytes), white blood cells (leukocytes), and platelets. In acquired aplastic anemia, an almost complete absence of hematopoietic stem cells results in low levels of red and white blood cells and platelets (pancytopenia). Symptoms of aplastic anemia are those of anemia, bleeding, and infection. Although bone marrow failure can occur secondary to other disorders, most aplastic anemia is due to the immune system mistakenly targeting the bone marrow (autoimmunity). Indeed, most patients can respond to therapy that suppresses the immune system, usually ATG and cyclosporine.
Aplastic anemia is classified as severe according to blood counts. Most of the discussion that follows relates to severe aplastic anemia. Patients with more moderately decreased blood counts; may not require treatment. Furthermore, some aplastic anemia that is genetically inherited may, first manifest in adulthood, sometimes without a family history of blood disease.
Aplastic Anemia & MDS International Foundation, Inc.
- 100 Park Avenue, Suite 108
- Rockville, MD 20850
- Tel: (301)279-7202
- Fax: (301)279-7205
- Tel: (800)747-2820
- Email: firstname.lastname@example.org
- Website: http://www.aamds.org
Aplastic Anemia & Myelodysplasia Association of Canada
- 11181 Yonge Street Suite 321
- Richmond Hill
- Ontario, L4S 1L2
- Tel: 9057800698
- Fax: 9057801648
- Tel: 8888400039
- Email: email@example.com
- Website: http://www.aamac.ca
Dubowitz Syndrome Support
- c/o 106 Verndale Street
- Warwick, RI 02889-3242
- Tel: (401)737-3138
- Email: firstname.lastname@example.org
- Website: http://www.dubowitzsyndrome.net
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
- Tel: (888)205-2311
- Website: http://rarediseases.info.nih.gov/GARD/
Julia's Wings Foundation, Inc.
- P.O. Box 581
- Sherman, CT 06784
- Tel: (860) 355-3653
- Fax: (860) 354-9860
- Email: email@example.com
- Website: http://www.juliaswings.org/
NIH/National Heart, Lung and Blood Institute
- P.O. Box 30105
- Bethesda, MD 20892-0105
- Tel: (301)592-8573
- Fax: (301)251-1223
- Email: firstname.lastname@example.org
- Website: http://www.nhlbi.nih.gov/
NIH/National Heart, Lung and Blood Institute ~ Hematology Branch
- 10 Center Dr, Building 10-CRC
- 3-5140, MSC-1202
- Bethesda, MD 20892-1202
- Tel: (301)496-5093
- Fax: (301)496-8396
- Tel: (800)644-2337
- Email: YoungNS@mail.nih.gov
- Website: http://dir.nhlbi.nih.gov/labs/hb/index.asp
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
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Last Updated: 8/5/2015
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