Wolf Hirschhorn Syndrome

National Organization for Rare Disorders, Inc.

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Important
It is possible that the main title of the report Wolf Hirschhorn Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • 4p- Syndrome, Partial
  • Chromosome 4, Partial Deletion 4p
  • Chromosome 4, Partial Monosomy 4p
  • Partial Deletion of the Short Arm of Chromosome 4
  • Pitt-Rogers-Danks Syndrome
  • WHCR
  • WHS
  • Wolf-Hirschhorn Chromosome Region (WHCR)
  • Wolf Syndrome

Disorder Subdivisions

  • None

General Discussion

Wolf-Hirschhorn syndrome is an extremely rare chromosomal disorder caused by a partial deletion (monosomy) of the short arm ("p") of chromosome 4. Major symptoms may include extremely wide-set eyes (ocular hypertelorism) with a broad or beaked nose, a small head (microcephaly), low-set malformed ears, mental and growth deficiency, heart (cardiac) defects, and seizures. Because the amount of genetic material deleted varies, the symptoms of this syndrome vary from case to case.

Supporting Organizations

4P- Support Group

131 Green Cook Road
Sunbury, OH 43074
USA
Tel: 740-936-5095
Email: president@4p-supportgroup.org
Website: http://4p-supportgroup.org/

Chromosome Disorder Outreach, Inc.

P.O. Box 724
Boca Raton, FL 33429-0724
USA
Tel: (561)395-4252
Fax: (561)395-4252
Email: info@chromodisorder.org
Website: http://www.chromodisorder.org/

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
Website: http://rarediseases.info.nih.gov/GARD/

Wolf Hirschhorn Syndrome Trust for the UK and Ireland

1 Hawthorne Villas
Holmes Chapel
Crewe, CW4 7AR
United Kingdom
Tel: 8456035338
Email: enquiries@whs4pminus.co.uk
Website: http://www.whs4pminus.co.uk

World Health Organization (WHO)

Avenue Appia 20
Geneva 27, 1211
Switzerland
Tel: 41227912111
Fax: 41227913111
Website: http://www.who.int/en/

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  12/27/1969
Copyright  2005 National Organization for Rare Disorders, Inc.