Tricho Dento Osseous Syndrome
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Tricho Dento Osseous Syndrome is not the name you expected.
Tricho-dento-osseous (TDO) syndrome is an autosomal dominant genetic disorder that belongs to a group of diseases known as ectodermal dysplasias. Ectodermal dysplasias typically affect the hair, teeth, nails, and/or skin. TDO syndrome is characterized by kinky or curly hair; poorly developed tooth enamel; and unusual thickness and/or denseness (sclerosis) of the top portion of the skull (calvaria) and/or the long bones (i.e., bones in the arms and legs). In some cases, affected individuals also exhibit abnormally thin, brittle nails or premature closure (fusion) of the fibrous joints between certain bones in the skull (craniosynostosis), causing the head to appear abnormally long and narrow (dolicocephaly).
There may be three distinct types of TDO syndrome. Some researchers suggest that these variants may be differentiated mainly by whether the calvaria and/or long bones exhibit abnormal hardening (sclerosis), thickening, and/or density. Other symptoms also vary among the three disorder types.
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Children's Craniofacial Association
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- Email: contactCCA@ccakids.com
- Website: http://www.ccakids.com
Craniofacial Foundation of America
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- Chattanooga, TN 37403
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FACES: The National Craniofacial Association
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- Chattanooga, TN 37401
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Genetic and Rare Diseases (GARD) Information Center
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- Gaithersburg, MD 20898-8126
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NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
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NIH/National Institute of Dental and Craniofacial Research
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National Foundation for Ectodermal Dysplasias
- 6 Executive Drive
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- Fairview Hights, IL 62208
- Tel: 618-566-2020
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- Website: http://www.nfed.org
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
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This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 4/22/2008
Copyright 2006 National Organization for Rare Disorders, Inc.
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