Health Information



Hyperemesis Gravidarum

National Organization for Rare Disorders, Inc.


It is possible that the main title of the report Hyperemesis Gravidarum is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Hyperemesis gravidarum (HG) is a rare disorder characterized by severe and persistent nausea and vomiting during pregnancy that may necessitate hospitalization. As a result of frequent nausea and vomiting, affected women experience dehydration, vitamin and mineral deficit, and the loss of greater than five percent of their original body weight.

Nausea and vomiting of pregnancy (NVP), more widely known as morning sickness, is a common condition of pregnancy. Many researchers believe that NVP should be regarded as a continuum of symptoms that may impact an affected woman's physical, mental and social well-being to varying degrees. Hyperemesis gravidarum represents the severe end of the continuum. No specific line exists that separates hyperemesis gravidarum from NVP; in most cases, affected individuals progress from mild or moderate nausea and vomiting to hyperemesis gravidarum. The exact cause of hyperemesis gravidarum is not known.


National Women's Health Resource Center

157 Broad Street,

Suite 106

Red Bank, NJ 07701

Tel: (732)530-3425

Fax: (732)530-3347

Tel: (877)986-9472



National Women's Health Network

1413 K Street, NW

4th Floor

Washington, DC 20005


Tel: (202)682-2640

Fax: (202)682-2648



National Healthy Mothers, Healthy Babies Coalition

4401 Ford Avenue

Suite 300

Alexandria, VA 22302


Tel: (703)837-4792

Fax: (703)664-0485



NIH/Office of Research on Women's Health

6707 Democracy Blvd Suite 400

Bethesda, MD 20892-5484

Tel: (301)402-1770

Fax: (301)402-1798



NIH/National Institute of Child Health and Human Development

31 Center Dr

Building 31, Room 2A32


Bethesda, MD 20892

Fax: (866)760-5947

Tel: (800)370-2943

TDD: (888)320-6942



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223


For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site or email

Last Updated:  1/20/2012

Copyright  1999, 2002, 2003, 2006, 2009, 2012 National Organization for Rare Disorders, Inc.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.