Lupus and Antiphospholipid Antibody Syndrome
About 1 out of 3 people with lupus produce an antibody that attacks certain blood-clotting factors, which can cause the blood to clot easily.1 A person who has this antibody and has had blood clots is said to have antiphospholipid antibody syndrome. This can lead to mild or severe blood-clotting complications, including:
- Stroke , transient ischemic attack (TIA), or heart attack.
- Deep vein thrombosis or pulmonary embolism.
- Multi-infarct dementia .
- Gangrene of fingers or toes.
- Kidney disease.
- Preeclampsia , premature birth, and miscarriage or stillbirth, apparently caused by blood circulation problems in the placenta.
A blood test can detect antiphospholipid antibodies. When diagnosed, the condition is usually treated with anticoagulants. Pregnant women with antiphospholipid antibody syndrome need to be closely monitored.
|Primary Medical Reviewer||Anne C. Poinier, MD - Internal Medicine|
|Specialist Medical Reviewer||Nancy Ann Shadick, MD, MPH - Internal Medicine, Rheumatology|
|Last Revised||May 10, 2012|
Last Revised: May 10, 2012
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