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pasireotide

Pronunciation: PAS i REE oh tide

Brand: Signifor

What is the most important information I should know about pasireotide?

Multum calldoc

Call your doctor at once if you have any signs that your cortisol levels are too low, such as: joint pain, muscle weakness, loss of appetite, weakness or tired feeling, weight loss, craving salty foods, mood changes, or irritability.

What is pasireotide?

Pasireotide is a man-made protein that is similar to a hormone in the body called somatostatin. Pasireotide lowers certain hormone substances produced in the body.

Pasireotide is used to treat Cushing's disease (an endocrine disorder). Pasireotide is usually given after surgery or other treatments have been tried without success.

Pasireotide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using pasireotide?

Multum donot

You should not use pasireotide if you are allergic to it.

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using pasireotide.

To make sure pasireotide is safe for you, tell your doctor if you have:

  • diabetes;
  • liver disease;
  • a heart rhythm disorder;
  • personal or family history of long QT syndrome;
  • gallbladder disease; or
  • a history of an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
Multum nopreg

FDA pregnancy category C. It is not known whether pasireotide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether pasireotide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is pasireotide given?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Pasireotide is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Use a different place on your stomach or thigh each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row. Avoid injecting pasireotide into skin that is swollen or irritated.

Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

Multum rt

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using pasireotide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of pasireotide?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have:

  • slow heart rate, feeling like you might pass out;
  • low cortisol levels--joint or muscle pain, muscle weakness, loss of appetite, tired feeling, weight loss, craving salty foods, mood changes, irritability;
  • high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or
  • gallbladder problem--chalky-colored stools, stomach pain just after eating a meal, nausea, heartburn, bloating, and severe upper stomach pain that may spread to your back.

Common side effects may include:

  • nausea, stomach pain, diarrhea;
  • headache;
  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • swelling in your hands or feet;
  • hair loss; or
  • pain, itching, redness, bruising, or bleeding where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pasireotide?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with pasireotide, especially:

  • bromocriptine;
  • cyclosporine;
  • methadone;
  • tacrolimus;
  • arsenic trioxide, vandetanib, vemurafenib;
  • an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine;
  • an antidepressant--amitriptyline, citalopram, clomipramine, desipramine;
  • anti-malaria medication--artemether and lumefantrine, chloroquine, halofantrine, mefloquine;
  • heart rhythm medicine--amiodarone, dofetilide, disopyramide, dronedarone, flecainide, ibutilide, procainamide, propafenone, quinidine, sotalol;
  • insulin or oral diabetes medication;
  • medicine to prevent or treat nausea and vomiting--dolasetron, droperidol, ondansetron;
  • medicine to treat a psychiatric disorder--chlorpromazine, clozapine, haloperidol, mesoridazine, pimozide, thioridazine, ziprasidone; or
  • migraine headache medicine--sumatriptan, zolmitriptan.

This list is not complete. Other drugs may interact with pasireotide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about pasireotide.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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