Health Information

 

 

glucarpidase

Pronunciation: gloo KAR pi dase

Brand: Voraxaze

What is the most important information I should know about glucarpidase?

To make sure you can safely receive glucarpidase, tell your doctor if you are also being treated with leucovorin.

Glucarpidase is usually given as a single injection.

Multum emt

To make sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. Do not miss any follow-up visits to your doctor.

Drink plenty of fluids to keep yourself hydrated while you are using glucarpidase. Follow your doctor's instructions about the type and amount of liquids you should drink.

Multum donot

Tell your caregiver right away if you have severe dizziness or weakness, severe nausea, cold sweat, itching, numbness or tingly feeling, sudden headache, fast heartbeats, chest tightness, trouble breathing, or if you feel like you might pass out.

What is glucarpidase?

Glucarpidase is used in patients who develop kidney failure while receiving high doses of methotrexate (a chemotherapy drug).

Glucarpidase is an enzyme that breaks down methotrexate in the body so the drug can be easily eliminated when the kidneys are not working properly.

Glucarpidase may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving glucarpidase?

To make sure you can safely receive glucarpidase, tell your doctor if you are also being treated with leucovorin.

Multum nopreg

FDA pregnancy category C. It is not known whether glucarpidase will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether glucarpidase passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is glucarpidase given?

Glucarpidase is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Glucarpidase is usually given as a single injection. The IV infusion will take about 5 minutes to complete.

Drink plenty of fluids to keep yourself hydrated while you are using glucarpidase. Follow your doctor's instructions about the type and amount of liquids you should drink.

Multum emt

To make sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. Do not miss any follow-up visits to your doctor.

What happens if I miss a dose?

Since glucarpidase is used as a single dose, it does not have a daily dosing schedule.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving glucarpidase?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of glucarpidase?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Some people receiving a glucarpidase injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you have:

  • severe dizziness or weakness;
  • severe nausea, feeling like you might pass out;
  • cold sweat, itching, numbness or tingly feeling;
  • sudden headache;
  • fast heartbeats, chest tightness; or
  • trouble breathing.

Less serious side effects may include:

  • mild nausea;
  • mild headache; or
  • mild numbness or tingling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect glucarpidase?

There may be other drugs that can interact with glucarpidase. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about glucarpidase.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 1.01. Revision date: 1/30/2012.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.