Health Information

 

 

omacetaxine

Pronunciation: OH ma se TAX een

Brand: Synribo

What is the most important information I should know about omacetaxine?

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Omacetaxine can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

What is omacetaxine?

Omacetaxine is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Omacetaxine is used to treat chronic myeloid leukemia (CML).

Omacetaxine is usually given after other cancer medications have been tried without success.

Omacetaxine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using omacetaxine?

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You should not use omacetaxine if you are allergic to it.

To make sure omacetaxine is safe for you, tell your doctor if you have:

  • diabetes; or
  • if you are pregnant or may become pregnant.
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FDA pregnancy category D. Do not use omacetaxine if you are pregnant. It could harm the unborn baby. Use effective birth control to avoid pregnancy during your treatment with omacetaxine. Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.

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It is not known whether omacetaxine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is omacetaxine given?

Omacetaxine is injected under the skin. A healthcare provider will give you this injection.

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If this medicine accidentally gets on your skin, wash it thoroughly with soap and warm water.

Omacetaxine can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your omacetaxine injection.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using omacetaxine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Avoid coming into contact with your body fluids (including urine, feces, vomit, semen, vaginal fluid). This medicine can pass into body fluids. Patients or caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

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This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of omacetaxine?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have:

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
  • high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss); or
  • severe skin rash.

Common side effects may include:

  • stomach pain, nausea, diarrhea, constipation;
  • joint pain;
  • headache, tired feeling,
  • swelling in your hands or feet;
  • temporary hair loss; or
  • pain, swelling, or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect omacetaxine?

Other drugs may interact with omacetaxine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about omacetaxine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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