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dalfampridine

Pronunciation: dal FAM pri deen

Brand: Ampyra

What is the most important information I should know about dalfampridine?

Multum donot

You should not use dalfampridine if you are allergic to it, or if you have moderate to severe kidney disease, if you have ever had a seizure (convulsions), or if you are also taking another multiple sclerosis drug called Fampridine.

Before you take dalfampridine, tell your doctor if you have kidney disease.

Multum emt

High doses of dalfampridine may increase your risk of seizure. Do not take more than 2 tablets in a 24-hour period. Do not use a tablet that has been broken or crushed. A broken tablet can release too much of the drug at one time.

Multum donot

Stop taking dalfampridine and call your doctor at once if you a seizure, pain or burning when you urinate, problems with your balance, numbness or tingly feeling, or a relapse of your MS symptoms.

What is dalfampridine?

Dalfampridine is a potassium channel blocker.

Dalfampridine is used to improve walking in patients with multiple sclerosis (MS).

Dalfampridine may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before taking dalfampridine?

Multum donot

You should not use dalfampridine if you are allergic to it, or if you have:

  • moderate to severe kidney disease;
  • if you have ever had a seizure (convulsions); or
  • if you are also taking another MS drug called Fampridine (4-aminopyridine).

To make sure you can safely take dalfampridine, tell your doctor if you have kidney disease.

Multum nopreg

FDA pregnancy category C. It is not known whether dalfampridine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication..

Multum nobrfeed

It is not known whether dalfampridine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using dalfampridine.

Multum nochild

Do not give this medication to anyone under 18 years old without the advice of a doctor.

How should I take dalfampridine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. High doses of dalfampridine may increase your risk of seizure. Follow the directions on your prescription label.

Dalfampridine is usually taken once every 12 hours. Follow your doctor's instructions.

Multum emt

Do not take more than 2 tablets in a 24-hour period.

Dalfampridine may be taken with or without food.

Multum nocrush

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Do not dissolve the tablet in liquid. Breaking or dissolving the pill may cause too much of the drug to be released at one time.

Multum donot

Do not use a dalfampridine tablet that has been accidentally crushed or broken. This can increase your risk of having a seizure.

To be sure this medication is not causing harmful effects, your kidney function may need to be checked with frequent blood tests. Visit your doctor regularly.

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Store at room temperature away from moisture and heat.

Throw away any leftover medicine after the expiration date on the label has passed.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause confusion, problems with thinking or memory, tremors, sweating, or seizures.

What should I avoid while taking dalfampridine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of dalfampridine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop taking dalfampridine and call your doctor at once if you have a serious side effect such as:

  • seizure (convulsions);
  • pain or burning when you urinate;
  • problems with balance;
  • numbness, burning pain, or tingly feeling;
  • relapse or worsening of MS symptoms;

Less serious side effects may include:

  • headache, dizziness;
  • sleep problems (insomnia);
  • nausea, constipation, upset stomach;
  • weakness;
  • stuffy nose, sinus pain, sore throat; or
  • back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dalfampridine?

There may be other drugs that can interact with dalfampridine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about dalfampridine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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