Health Information

 

 

azacitidine

Pronunciation: ay za SYE ti deen

Brand: Vidaza

What is the most important information I should know about azacitidine?

Multum nopreg

Do not use azacitidine if you are pregnant. It could harm the unborn baby.

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You should not receive this medication if you are allergic to azacitidine or mannitol, or if you have liver cancer.

Before receiving azacitidine, tell your doctor if you have kidney disease, liver disease, or a history of liver cancer.

If a man fathers a baby while using azacitidine, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment. Continue using condoms for at least 4 weeks after you stop using azacitidine.

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Tell your caregiver right away if this medication accidentally gets on your skin. Wash the area thoroughly with soap and warm water.

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Azacitidine can lower blood cells that help your body fight infections and help your blood to clot. Your blood may need to be tested often. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding injury. Tell your doctor at once if you develop signs of infection.

Multum donot

Do not receive a "live" vaccine while you are being treated with azacitidine, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you.

What is azacitidine?

Azacitidine is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Azacitidine is used to treat certain types of bone marrow cancers and blood cell disorders.

Azacitidine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving azacitidine?

Multum donot

You should not receive this medication if you are allergic to azacitidine or mannitol, or if you have liver cancer.

To make sure you can safely receive azacitidine, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • liver disease; or
  • a history of liver cancer.
Multum nopreg

FDA pregnancy category D. Do not use azacitidine if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Use birth control to prevent pregnancy while you are receiving azacitidine, whether you are a man or a woman. Azacitidine use by either parent may cause birth defects.

If a man fathers a baby while using azacitidine, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment. Continue using condoms for at least 4 weeks after you stop using azacitidine.

Multum nobrfeed

It is not known whether azacitidine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using azacitidine.

How is azacitidine given?

Azacitidine is injected under the skin or into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Azacitidine must be given slowly, and the IV infusion can take up to 40 minutes to complete. If you are receiving a shot under your skin, you may require two injections to complete your dose.

You may also be given medications to reduce nausea and vomiting while you are receiving azacitidine.

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This medication is usually given for 7 days in a row every 4 weeks for at least 4 treatment cycles. Your treatment schedule may be different. Follow your doctor's instructions.

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Tell your caregiver right away if this medication accidentally gets on your skin. Wash the area thoroughly with soap and warm water.

Multum emt

Azacitidine can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Visit your doctor regularly.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your azacitidine injection.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while using azacitidine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Multum donot

Do not receive a "live" vaccine while using azacitidine, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.

What are the possible side effects of azacitidine?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have a serious side effect such as:

  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • redness, swelling, warmth, oozing, or other signs of skin infection;
  • sudden chest pain or discomfort, wheezing, dry cough or hack;
  • severe ongoing nausea, vomiting, or diarrhea;
  • burning or skin changes where the injection was given;
  • lower back pain, blood in your urine, urinating less than usual or not at all;
  • numbness or tingly feeling around your mouth;
  • muscle weakness, tightness, or contraction, overactive reflexes;
  • fast or slow heart rate, weak pulse, confusion, fainting; or
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).

Less serious side effects may include:

  • mild nausea, vomiting, loss of appetite;
  • stomach pain, diarrhea, constipation;
  • feeling weak or tired;
  • pain, redness, bruising, or other irritation where the injection was given;
  • headache, dizziness;
  • anxiety, sleep problems (insomnia);
  • joint or muscle pain; or
  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect azacitidine?

There may be other drugs that can interact with azacitidine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about azacitidine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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