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etonogestrel (implant)

Pronunciation: e toe noe JES trel

Brand: Implanon, Nexplanon

What is the most important information I should know about etonogestrel implant?

Multum nopreg

Do not use an etonogestrel implant if you are pregnant. If you have recently had a baby, wait at least 3 weeks (4 weeks if breast-feeding) before receiving an etonogestrel implant.

Multum donot

You should not use this implant if you are allergic to etonogestrel, or if you have any of the following conditions: unusual vaginal bleeding, liver disease or liver cancer, or if you have ever had breast or uterine cancer, a heart attack, a stroke, or a blood clot.

Before receiving the etonogestrel implant, tell your doctor if you have diabetes, high blood pressure, high cholesterol, gallbladder disease, kidney disease, an ovarian cyst, headaches, a history of depression, if you are overweight, or if you are allergic to numbing medicines.

Etonogestrel implant is inserted through a needle into the skin of your upper arm. The medicine is released slowly into the body from the implant. The implant can remain in place to provide continuous contraception for up to 3 years.

Multum donot

You will most likely have irregular and unpredictable periods while using the etonogestrel implant. Tell your doctor if your periods are very heavy or long-lasting, or if you miss a period (you may be pregnant).

Multum emt

If you need surgery or medical tests or if you will be on bed rest, you may need to have your etonogestrel implant removed for a short time. Any doctor or surgeon who treats you should know that you have an etonogestrel implant.

The etonogestrel implant must be removed by the end of the third year after it was inserted and may be replaced at that time with a new implant. If you choose not to replace the implant, your ability to get pregnant will return quickly. Start using another form of birth control right away if you wish to avoid an unintended pregnancy.

What is etonogestrel implant?

Etonogestrel implant contains a hormone that prevents ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Etonogestrel implant is used as contraception to prevent pregnancy. The medicine is contained in a small plastic rod that is implanted into the skin of your upper arm. The medicine is released slowly into the body. The rod can remain in place and provide continuous contraception for up to 3 years.

Etonogestrel implant may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving the etonogestrel implant?

Multum nopreg

Do not use an etonogestrel implant if you are pregnant. If you have recently had a baby, wait at least 3 weeks (4 weeks if breast-feeding) before receiving an etonogestrel implant.

Multum donot

You should not use this implant if you are allergic to etonogestrel, or if you have:

  • a history of heart attack, stroke, or blood clot;
  • a history of hormone-related cancer such as breast or uterine cancer;
  • unusual vaginal bleeding that has not been checked by a doctor; or
  • liver disease or liver cancer.

To make sure you can safely use the etonogestrel implant, tell your doctor if you have any of these other conditions:

  • diabetes;
  • high cholesterol or triglycerides, or if you are overweight;
  • high blood pressure;
  • headaches;
  • gallbladder disease;
  • kidney disease;
  • an ovarian cyst;
  • a history of depression; or
  • if you are allergic to numbing medicines.

The etonogestrel implant should not be used in girls younger than 18 years old.

Multum nobrfeed

Do not use the implant if you are breast-feeding a baby younger than 4 weeks old.

How is the etonogestrel implant used?

Etonogestrel implant is inserted through a needle into the skin of your upper arm, just inside and above the elbow. The implant will be placed in your arm under local anesthetic in your doctor's office or other clinic setting.

Multum nopreg

Before receiving this implant, you may need a pregnancy test to make sure you are not pregnant.

The timing of when you will receive this implant depends on whether or not you were using birth control before, and what type it was. Follow your doctor's instructions.

This implant must be inserted only by a physician or other healthcare provider who has been specially trained in the insertion of the etonogestrel implant. Incorrect placement of the rod too deeply can make it difficult or impossible to remove later on. If the rod is incorrectly inserted and falls out, you will not be protected from unintended pregnancy.

Once the implant is inserted, you should be able to feel it under your skin. Tell your doctor if you cannot feel the implant under the skin at any time while it is in place.

Etonogestrel is released slowly into the body from the implant. The implant can remain in place to provide continuous contraception for up to 3 years. If the implant is placed correctly, you will not need to use back-up birth control. Follow your doctor's instructions.

Multum emt

After the implant is inserted, your doctor will cover your arm with two bandages. You may remove the top bandage after 24 hours, but leave the smaller bandage on your arm for 3 to 5 days. Keep the area clean and dry while wearing the bandage.

Multum donot

You will most likely have irregular and unpredictable periods while using the etonogestrel implant. Tell your doctor if your periods are very heavy or long-lasting, or if you miss a period (you may be pregnant).

Your doctor will need to see you on a regular basis while you are using this medication. You may also need to have routine mammograms. Do not miss any appointments.

Multum emt

If you need surgery or medical tests or if you will be on bed rest, you may need to have your etonogestrel implant removed for a short time. Any doctor or surgeon who treats you should know that you have an etonogestrel implant.

The etonogestrel implant must be removed by the end of the third year after it was inserted and may be replaced at that time with a new implant. If you choose not to replace the implant, your ability to get pregnant will return quickly. Some women have become pregnant within the first week after removal of an etonogestrel implant. Start using another form of birth control right away if you wish to avoid an unintended pregnancy.

Multum donot

Do not use etonogestrel implants for longer than recommended by your doctor.

What happens if I miss a dose?

Since etonogestrel is given as an implant by a healthcare professional, you will not be on a frequent dosing schedule. Be sure to see your doctor for removal of the implant by the end of the third year.

What happens if I overdose?

Multum emt

If the implant is correctly inserted, an overdose of etonogestrel is highly unlikely. Overdose symptoms may include nausea, vomiting, and vaginal bleeding.

What should I avoid while taking etonogestrel implant?

Multum smoking

Do not smoke while using etonogestrel implant, especially if you are older than 35. Smoking can increase your risk of blood clots, stroke, or heart attack caused by etonogestrel implant.

Etonogestrel implant will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.

What are the possible side effects of etonogestrel implant?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have any of these serious side effects:

  • warmth, redness, swelling, or oozing where the implant was inserted;
  • sudden numbness or weakness, especially on one side of the body;
  • severe pain or cramping in your pelvic area (may be only on one side);
  • sudden severe headache, confusion, pain behind the eyes, problems with vision, speech, or balance;
  • sudden cough, wheezing, rapid breathing, coughing up blood;
  • pain, swelling, warmth, or redness in one or both legs;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • a breast lump;
  • swelling in your hands, ankles, or feet;
  • jaundice (yellowing of the skin or eyes);
  • symptoms of depression (sleep problems, weakness, tired feeling, mood changes); or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • pain, numbness, or tingling where the implant was inserted;
  • minor bleeding or scarring where the implant was inserted;
  • menstrual cramps, changes in your menstrual periods;
  • mild headache, dizziness, mood changes;
  • vaginal itching or discharge;
  • breast pain;
  • acne;
  • problems with contact lenses;
  • nausea, mild stomach pain;
  • back pain;
  • feeling nervous or depressed;
  • sore throat, flu symptoms; or
  • weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect etonogestrel implant?

Some drugs can make etonogestrel less effective, which may result in pregnancy. Before receiving this implant, tell your doctor if you are using any of the following drugs:

  • bosentan (Tracleer);
  • dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
  • griseofulvin (Fulvicin, Grifulvin);
  • rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);
  • antifungal medication such as itraconazole (Sporanox) or ketoconazole (Nizoral);
  • a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
  • drugs to treat hepatitis C, HIV, or AIDS;
  • medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil);
  • St. John's wort; or
  • seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and other drugs may interact with etonogestrel. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about etonogestrel implant.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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