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chlorothiazide

Pronunciation: KLOR oh THYE a zide

Brand: Diuril

Chlorothiazide 250 mg-MYL

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Chlorothiazide 500 mg-MYL

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Diuril 250 mg

round, white, imprinted with DIURIL, MSD 214

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Diuril 500 mg

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What is the most important information I should know about chlorothiazide?

Multum donot

Do not use this medication if you are allergic to chlorothiazide or if you are unable to urinate.

Before using this medication, tell your doctor if you are allergic to sulfa drugs, or if you have liver disease, kidney disease, asthma, allergies, gout, lupus, or diabetes.

Multum noalcohol

Avoid drinking alcohol, which can increase some of the side effects of chlorothiazide.

Multum dizzy

Tell your doctor if you regularly use other medicines that make you light-headed (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to the side effects of chlorothiazide.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

What is chlorothiazide?

Chlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Chlorothiazide treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. This medication is also used to treat high blood pressure (hypertension).

Chlorothiazide may also be used for other purposes not listed in this medication guide.

What should I discuss with my doctor before taking chlorothiazide?

Multum donot

Do not use this medication if you are allergic to chlorothiazide, or if you are unable to urinate.

If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before taking chlorothiazide, tell your doctor if you have:

  • kidney disease;
  • liver disease;
  • asthma or allergies;
  • gout;
  • lupus;
  • diabetes; or
  • if you are allergic to sulfa drugs.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take chlorothiazide.

Multum nopreg

FDA pregnancy category C. It is not known whether chlorothiazide is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

Multum nobrfeed

Chlorothiazide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take chlorothiazide?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Do not miss any scheduled appointments.

Your blood and urine may need to be tested if you have been vomiting or are dehydrated.

Chlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

Multum rt

Store the tablets at room temperature away from heat, light, and moisture.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, and muscle weakness or limp feeling.

What should I avoid while taking chlorothiazide?

Multum noalcohol

Avoid drinking alcohol, which can increase some of the side effects of chlorothiazide.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

What are the possible side effects of chlorothiazide?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • nausea and vomiting with weakness, loss of appetite, headache, hallucinations, muscle pain, and/or seizure;
  • confusion, uneven heart rate, extreme thirst, leg discomfort, muscle weakness or limp feeling;
  • urinating more or less than usual or not at all;
  • easy bruising or bleeding;
  • numbness or tingly feeling;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • dizziness, spinning sensation;
  • diarrhea, constipation, stomach cramps;
  • muscle spasm;
  • loss of interest in sex; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chlorothiazide?

Multum dizzy

Tell your doctor if you regularly use other medicines that make you light-headed (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to the side effects of chlorothiazide.

Before taking this medication, tell your doctor if you are using any of the following drugs:

  • lithium;
  • digoxin (Lanoxin);
  • cholestyramine (Prevalite, Questran) or colestipol (Colestid);
  • steroids (prednisone and others);
  • other blood pressure medications;
  • NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), indomethacin, naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others; or
  • insulin or diabetes medicine taken by mouth.

This list is not complete and there may be other drugs that can interact with chlorothiazide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about chlorothiazide.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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