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acetaminophen (rectal)

Pronunciation: a SEET a MIN oh fen

Brand: Acephen, Feverall, Mapap, Uniserts

What is the most important information I should know about acetaminophen?

Multum donot

Do not use more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Know the amount of acetaminophen in the specific product you are using.

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Do not use this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to use acetaminophen.

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Avoid drinking alcohol. It may increase your risk of liver damage while using acetaminophen.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have liver disease or a history of alcoholism.

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Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Using certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

What is acetaminophen?

Acetaminophen is a pain reliever and a fever reducer.

Acetaminophen rectal is given as a suppository to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.

Acetaminophen may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using acetaminophen?

Multum donot

You should not use acetaminophen if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to use acetaminophen if you have:

  • liver disease; or
  • a history of alcoholism.
Multum emt

Do not use this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to use acetaminophen.

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FDA pregnancy category C. Your doctor will determine whether acetaminophen is safe for you to use during pregnancy. Do not use this medicine without the advice of your doctor if you are pregnant.

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Acetaminophen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use acetaminophen?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Multum donot

Do not use more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

One acetaminophen suppository may contain up to 650 mg of acetaminophen. Know the amount of acetaminophen in the specific product you are using.

If you are treating a child, use a pediatric form of acetaminophen. Carefully follow the dosing directions on the medicine label. Do not give the medication to a child younger than 2 years old without the advice of a doctor.

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Do not take an acetaminophen rectal suppository by mouth. It is for use only in your rectum.

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Wash your hands before and after inserting the suppository.

Try to empty your bowel and bladder just before using the acetaminophen suppository.

Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.

For best results from the suppository, lie down and insert the suppository pointed tip first into the rectum. Hold in the suppository for a few minutes. It will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom just after inserting the suppository.

Multum emt

Stop using acetaminophen and call your doctor if:

  • you still have a fever after 3 days of use;
  • you still have pain after 10 days of use (or 5 days if treating a child);
  • you have a sore throat, high fever, or nausea and vomiting;
  • you have a skin rash, ongoing headache, or any redness or swelling; or
  • if your symptoms get worse, or if you have any new symptoms.

Acetaminophen can cause false results with certain lab tests for glucose (sugar) in the urine. Talk to your doctor if you are diabetic and you notice changes in your glucose levels during treatment.

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Store at room temperature away from heat and moisture.

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The rectal suppositories may also be stored in the refrigerator. Do not allow the medicine to freeze.

What happens if I miss a dose?

Since acetaminophen is used as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

What should I avoid while using acetaminophen?

Multum donot

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Using certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of liver damage while using acetaminophen.

What are the possible side effects of acetaminophen?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • low fever with nausea, stomach pain, and loss of appetite;
  • dark urine, clay-colored stools; or
  • jaundice (yellowing of the skin or eyes).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect acetaminophen?

There may be other drugs that can interact with acetaminophen. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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